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More possibilities means less chances to breed the dragon you are aiming for. When you use multiple element dragons, you introduce more elements and more possibilities.
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However, you may find with the level 2's that you need to use some double elements to unlock. But if you want to breed a certain dragon, then Single element dragons are best. You can doubt this if you want, and even go test it out to prove it to yourself.
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I do have a spreadsheet that has all of them, but I can't post the spreadsheet, so if you are really stuck and can't figure one out, just send me a DM and I'll get back to you. This guide also ignores epics, VR's, rares and commons since you don't really need my advice on how to breed them for the most part, and because you are going to get most, if not all of them, in the process of breeding the legendaries in the form of mis-breeds. The new system probably does effect how they are bred, however if you are hell bent on breeding them like they used to, then just go to the app store and download and play on a version of DC older than 10.8. They have been covered other places already.
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